Worst case scenario is them regaining their memories as a bijuu. Second worst case scenario is their personality as a bijuu waking up separately. Somewhere down the line is their memories from a previous jinchuuriki incarnation waking up.
Any of these and more can lead to the collapse of the whole house of cards.
Any of these and more can lead to the collapse of the whole house of cards.
Or maybe that's just how Jinchuurikis are in that world.
You sacrifice a human being to serve as a body for a bijuu, while locking their power down (so it can be controlled) along with their memories (so THEY can be controlled)