PDV
Revelation That Uncertainty Is Itself An Answer
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Sort of. Increases Openness to Experience, which is generally correlated with success in some ways like the other three of the Big Five (and the inverse of Neuroticism, the fifth). Do it too much and, well, it's unethical to experiment too extensively but based on the sample of scientists who experimented before they knew what the effects were, 'have an open mind but not so open your brain falls out' is more literal than you might expect.Hey, use of LSD and other such drugs has been shown to have positive results for mental health.
Though MDMA is rather different both in mechanism of action and effects, and definitely has some seriously beneficial psych effects. Actually, MDMA therapy is probably approximately ideal for Lex, if he could stand it, which probably he couldn't; it's principally used for trauma treatment, but would probably help enormously with paranoia. But it produces strong feelings of emotional openness and vulnerability as a direct part of its beneficial properties, which I can't see even the healthier Lexes like Inviolate!Lex tolerating.